MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202631024881 A) filed by Ramakrishna Mission Residential College, Kolkata, West Bengal, on March 2, for '2-deoxy-d-glucose, sauropunol compounds and method of preparing the same.'
Inventor(s) include Joykrishna Maity; Abhinash Subba; Ratul Hore; Anirban Pradhan; and Sukhen Mandal.
The application for the patent was published on March 13, under issue no. 11/2026.
According to the abstract released by the Intellectual Property India: "A process for the preparation of 2-deoxy-D-glucose (2-DG) and its 3,6-anhydro derivatives including sauropunols from D-glucose is disclosed. The process comprises benzoylation of a D-glucose derived compound to form a protected intermediate, followed by acid-catalyzed alcoholysis to produce alkyl-3,5,6-tri-O-benzoyl-D-glucofuranosides. The intermediates undergo thiocarbonyl formation and radical-mediated deoxygenation to selectively remove the hydroxyl group at the C-2 position. Subsequent removal of protecting groups yields intermediates that are converted either by hydrolysis to obtain 2-deoxy-D-glucose or by base-mediated intramolecular cyclization followed by hydrolysis to form 3,6-anhydro sugar derivatives including sauropunols. The process provides a unified synthetic pathway from D-glucose with improved overall yields and also enables preparation of intermediates useful for synthesizing other biologically important amino-sugar derivatives."
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