MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202611023979 A) filed by Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, on Feb. 27, for 'a dual-trigger, multilayer, directionally-controlled nanostructured buccal film system for programmable biphasic transmucosal analgesic delivery.'
Inventor(s) include Dr. Charu Saxena.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a multilayer, directionally-controlled biphasic buccal film comprising trigger-responsive nanoparticle domains for programmable transmucosal analgesic delivery. The film includes an immediate-release surface layer containing first drug-loaded nanoparticles having a particle size of 50-100 nm, a diffusion-modulating interlayer, a sustained release biodegradable nanoparticle reservoir layer comprising second drug-loaded nanoparticles having a particle size of 200-400 nm, and a unidirectional impermeable backing layer configured to restrict reverse drug diffusion. Upon buccal application, hydration-triggered activation of the surface layer produces rapid drug release within 5-15 minutes, followed by diffusion-controlled and pH-responsive sustained release from the reservoir layer over 6-12 hours. The system generates a programmable biphasic plasma concentration profile while minimizing burst release. The multilayer architecture enhances systemic bioavailability by bypassing hepatic first-pass metabolism, reduces dosing frequency, improves patient compliance, and provides a non-invasive alternative to conventional oral and injectable analgesic delivery systems."
Disclaimer: Curated by HT Syndication.
