MUMBAI, India, July 5 -- Intellectual Property India has published a patent application (202311086230 A) filed by Council Of Scientific And Industrial Research, New Delhi, on Dec. 15, 2023, for 'a method for production of bioactive withanolides from withania somnifera.'
Inventor(s) include Karuna Shanker; Mausam Singh; Neerja Tiwari; Ramdas; Amrat Pal Singh; Puja Khare; Kapil Dev; Rajesh Kumar Verma; Saudan Singh; and Prabhodh Kumar Trivedi.
The application for the patent was published on July 4, under issue no. 27/2025.
According to the abstract released by the Intellectual Property India: "The present invention relates to a to a new process technology for the extraction, enrichment and simultaneous production of four withanolides (withanoside-IV, withaferin-A, withanolide-A and withanone) of formulae (1) from Ashwagandha (Withania somnifera) and other plants and products therefrom. The process comprises preparation of most suitable homogeneous binary/ ternary/ quaternary/ tetra mixture of deep eutectic solvent (DES) as extractant characterized by brix degree; preparation of de-chlorophyll withanolides rich extract from dry/fresh roots/leaves/stem of cultivated/wild varieties of W. somnifera, using aforesaid DES solution by hot/ultrasonic extraction; enrichment with organic solvent probably ethyl acetate/ chloroform by trituration/liquid-liquid partitioning ; and simultaneous isolation of withanoside-IV, withaferin-A, withanolide-A and withanone of appreciable purity by flash chromatography in a single run without additional step of purification. These withanolides are having pharmacological/ therapeutic/ cosmeceutical significance with anti-Alzheimer, anti-stress, and neuroprotective and bone formation activities."
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