MUMBAI, India, Jan. 2 -- Intellectual Property India has published a patent application (202541125393 A) filed by Anurag University, Hyderabad, Telangana, on Dec. 11, 2025, for 'a method for protecting liver tissue from toxin-induced oxidative damage using biotin.'
Inventor(s) include Divya Amaravadi; Dr. Vasudha Bakhshi; and Ravali Gundi.
The application for the patent was published on Jan. 2, under issue no. 01/2026.
According to the abstract released by the Intellectual Property India: "The present invention discloses a method (100) for preventing and treating thioacetamide-induced hepatic injury using Biotin as a hepatoprotective and antioxidant agent. The method comprises selecting a subject (101), inducing hepatic injury using Thioacetamide at 350 mg/kg (102), administering Biotin at doses of 3 mg/kg and 6 mg/kg (103), reducing elevated hepatic marker enzymes including AST, ALT, and total bilirubin (104), enhancing endogenous antioxidant enzymes including SOD, catalase, and reduced glutathione (105), and preventing liver fibrosis and inflammatory cell infiltration with preservation of normal hepatic architecture (106). The method is validated using biochemical, antioxidant, and histopathological evaluations in female Wistar rats. The invention provides a safe, effective, and affordable therapeutic approach for oxidative stress-induced liver disorders."
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