MUMBAI, India, Nov. 21 -- Intellectual Property India has published a patent application (202511079666 A) filed by Noida Institute Of Engineering & Technology, Greater Noida, Uttar Pradesh, on Aug. 22, for 'a method for the synthesis and antiepileptic evaluation of piperazine, 1,3,4-oxadiazole, and quinoline conjugates.'
Inventor(s) include Ms Shristi Tripathi; Dr Rajnish Kumar; Dr Avijit Mazumder; Dr Salahuddin; Mr Ranjeet Kumar Yadav; and Mr Himanshu Singh.
The application for the patent was published on Nov. 21, under issue no. 47/2025.
According to the abstract released by the Intellectual Property India: "Disclosed herein is a method for the synthesis and antiepileptic evaluation of piperazine, 1,3,4-oxadiazole, and quinoline conjugates (100) includes providing LR-grade solvents and chemicals (102), followed by synthesizing various derivatives such as 2-chloro-1-(piperazine-1-yl) ethanone, 2-phenylquinoline-4-carboxylic acid, and final conjugates (11a-11i) (104). The synthesized compounds are characterized (106) using instruments including a Mettler Toledo balance, Lab India melting point apparatus, Shimadzu IR spectrometer, Bruker 500 MHz NMR, and mass spectrometry. In-silico analysis (108) is conducted using MarvinSketch and ChemDraw Pro, while molecular docking (110) with 4COF protein is done via AutoDock 4.2. ADME properties are predicted computationally (112). Pharmacological testing involves formulating stock solutions (114) using PEG-200, conducting acute toxicity studies (116) per OECD-423, and assessing antiepileptic efficacy via MES test in mice (118). Neurotoxicity is evaluated (120) using the rotarod test to observe motor coordination impairment."
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