MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202611007751 A) filed by Swami Vivekananda Subharti University, Meerut, Uttar Pradesh, on Jan. 27, for 'a pharmaceutical composition comprising cyano-substituted quinolone derivatives and a method for their synthesis and use as potent antibacterial agents.'
Inventor(s) include Dr. Vikrant Verma.
The application for the patent was published on March 13, under issue no. 11/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a pharmaceutical composition comprising at least one cyano-substituted quinolone derivative of Formula I, wherein the quinolone core incorporates a cyano group at the 6-position in place of the traditional 6-fluoro substituent found in fluoroquinolones. This structural modification provides enhanced antibacterial potency, improved chemical stability, and reduced minimum inhibitory concentration (MIC) values against Gram-positive and Gram-negative pathogens. The invention further provides an improved method for synthesizing the cyano-quinolone derivatives through protonation, selective amine substitution, and high-yield cyclization using DMFDMA, ortho-xylene, and p-toluenesulfonic acid, followed by purification and analytical characterization. Additionally, the invention discloses methods for evaluating antibacterial efficacy through MIC determination and time-kill assays, demonstrating superior activity compared to conventional fluoroquinolones. The composition may be formulated into various dosage forms and offers a potent, stable, and therapeutically advantageous alternative for treating bacterial infection."
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