MUMBAI, India, Oct. 31 -- Intellectual Property India has published a patent application (202411030588 A) filed by Indian Council Of Medical Research; and Centre For Liver Research And Diagnostics, Deccan College Of Medical Sciences, New Delhi, on April 16, 2024, for 'a process of identifying potent vaccine candidate against human glioblastoma and method of preparing thereof.'
Inventor(s) include Fathima, Nusrath; Vishwakarma, Sandeep Kumar; and Khan, Aleem Ahmed.
The application for the patent was published on Oct. 31, under issue no. 44/2025.
According to the abstract released by the Intellectual Property India: "The present invention relates to a process of identification of targeted molecular candidate vaccine within the human glioblastoma-derived exosomes which can be used for priming human dendritic cells. Said process includes the steps of: (a) culturing a tissue sample; (b) washing and cleaning the tissue sample with a salt solution; (c) mixing the tissue sample with a digestive enzyme and incubating the same at 37 C in a water bath for 30 to 60 minutes to allow digestion; (d) centrifuging the digested tissue sample two times and culturing in-vitro the centrifuged tissue sample to obtain 70-80% confluency; (e) isolating exosomes from the above-cultured tissue sample; (f) characterizing the isolated exosomes; (g) priming human dendritic cells (DCs) with the characterized exosomes to obtain targeted molecular candidate vaccine i.e., dexosomes. Further, the present disclosure provides the exosomes derived from primed DCs (dexosomes) presents an effective therapeutic vaccine candidate to combat human glioblastoma."
Disclaimer: Curated by HT Syndication.
