MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202611026457 A) filed by Integral University, Lucknow, Uttar Pradesh, on March 6, for 'a sucrose-assisted hepatic targeting system for enhanced liver distribution of ursodeoxycholic acid.'
Inventor(s) include Anas Khan; Dr. Mohammad Khushtar; Dr. Badruddeen; Dr. Mohd Ajmal; Saurabh Kumar Chauhan; Rehan Umar; Abubakar; and Dr. Nasreen Jahan.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a sucrose-assisted hepatic targeting system for enhancing the liver distribution of ursodeoxycholic acid (UDCA). Ursodeoxycholic acid is a widely used bile acid for the management of hepatobiliary disorders; however, its hepatic distribution following oral administration is often limited, resulting in variable liver exposure. The invention provides a pharmaceutical composition and method wherein co-administration of sucrose with ursodeoxycholic acid significantly enhances the accumulation of UDCA in hepatic tissue. Sucrose functions as a physiologically acceptable delivery-enhancing agent, promoting preferential hepatic uptake without altering the chemical structure or pharmacological identity of UDCA. Experimental evaluation in animal models demonstrated a marked increase in liver concentration of ursodeoxycholic acid when administered in combination with sucrose compared to ursodeoxycholic acid alone. The invention offers a simple, safe, and effective approach for improving liver-specific distribution of ursodeoxycholic acid and may be applicable to other drugs requiring enhanced hepatic targeting."
Disclaimer: Curated by HT Syndication.
