MUMBAI, India, July 11 -- Intellectual Property India has published a patent application (202541053305 A) filed by Ramanujam Narayanan; and Dr. Sivaselvakumar Muthusamy Address Of Applicant, Coimbatore, Tamil Nadu, on June 2, for 'an inhalation chamber for whole-body pharmacology drug evaluations and toxicology risk assessments in laboratory rodents.'
Inventor(s) include Ramanujam Narayanan; and Dr. Sivaselvakumar Muthusamy.
The application for the patent was published on July 11, under issue no. 28/2025.
According to the abstract released by the Intellectual Property India: "A whole-body rodent inhalational chamber to perform risk assessment of volatile pollutants and aerosols of drugs is prudent to evaluate their toxicological effects (for pollutants) and pulmonary effects (drug aerosols). Methodology: Prior IAEC approval was obtained. A novel inhalation chamber was designed, constructed and optimized for pollutant evaluation in mouse and possibly rats. The air fluidic flow rates were simulated to optimize the design for best results. Results: The inhalational chamber has five components - an inlet, a chamber for animal exposure, outlets, the connection tubes and valves and the chamber environment. The optimum flow rate based on simulation was 15 lpm. The chamber has five detectors - oxygen saturation, carbon dioxide level, relative humidity, temperature and pressure, which are read every thirty seconds, to secure animal welfare and characterize experimental conditions. Discussion and conclusion: The chamber has been validated as per OECD guidelines for environmental volatile and semi-volatile pollutants like air pollutants in mouse model. The test substances (Polychlorinated Biphenyls) were deposited in lower airways with minimum airway inflammation but with extensive systemic toxicities. Finally, animal welfare checkpoints were met with in this design as a novel outcome measure. Keywords: Inhalation, Rodent, Exposure chamber, airway inflammation, Toxicology, Aerosols."
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