MUMBAI, India, Nov. 7 -- Intellectual Property India has published a patent application (202441034771 A) filed by Dr. K. Bhavyasri; Sanjeeva Reddy Chinnakadoori; Sudha Divya Madhuri Kallam; Anoop Bodapati; Phanikumar Reddy Satti; Bhaskar Vallamkonda; Mylsamy Palanisamy; Venkata Lakshamana Sagar Dantinapalli; and Selvaraj Elumalai, Hyderabad, Telangana, on May 2, 2024, for 'bioanalytical method and system for quantifying molnupiravir in biological sample.'
Inventor(s) include Dr. K. Bhavyasri; Sanjeeva Reddy Chinnakadoori; Sudha Divya Madhuri Kallam; Anoop Bodapati; Phanikumar Reddy Satti; Bhaskar Vallamkonda; Mylsamy Palanisamy; Venkata Lakshamana Sagar Dantinapalli; and Selvaraj Elumalai.
The application for the patent was published on Nov. 7, under issue no. 45/2025.
According to the abstract released by the Intellectual Property India: "The present invention related to a bioanalytical method and system for quantifying Molnupiravir in biological samples, particularly rat plasma, using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The method involves liquid-liquid extraction (LLE) of Molnupiravir and utilization of D7-Molnupiravir as an internal standard (IS). A Phenyl column with a specific mobile phase composition is employed for drug separation. Positive mode multiple reaction monitoring (MRM) enables simultaneous detection of Molnupiravir and D7-Molnupiravir. The method demonstrates high selectivity, specificity, linearity, precision, accuracy, and stability under various conditions, meeting regulatory standards. This novel approach offers a rapid, efficient, and reliable means for quantifying Molnupiravir in biological samples, facilitating pharmacokinetic studies and therapeutic monitoring."
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