MUMBAI, India, Jan. 2 -- Intellectual Property India has published a patent application (202541123232 A) filed by Vellore Institute Of Technology, Vellore, Tamil Nadu, on Dec. 6, 2025, for 'bioinformatics method for identifying anti-biofilm glycosyl hydrolases.'
Inventor(s) include Dr. Rohit; and Ms. Maria Anna Anil.
The application for the patent was published on Jan. 2, under issue no. 01/2026.
According to the abstract released by the Intellectual Property India: "The present disclosure provides a computer-implemented method for identifying anti-biofilm glycosyl hydrolases across microbial species. The method includes retrieving protein sequences of pslG homologs from bacterial and fungal species using sequence similarity searches against genomic databases, performing domain prediction analysis on the retrieved protein sequences to identify glycosyl hydrolase family 39 (GH39) domains, conducting phylogenetic analysis to determine evolutionary relationships among GH39-containing proteins across the bacterial and fungal species, selecting fungal GH39 proteins that exhibit phylogenetic similarity to Pseudomonas aeruginosa pslG, predicting three-dimensional protein structures of the selected fungal GH39 proteins using computational modeling, and performing structural comparison between the predicted fungal GH39 protein structures and a bacterial pslG protein structure to assess structural conservation. The bioinformatics workflow system (FIG. 1) enables systematic identification of functionally conserved anti-polysaccharide enzymes across diverse microbial taxa through comprehensive sequence analysis, domain prediction, and phylogenetic comparison."
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