MUMBAI, India, Aug. 1 -- Intellectual Property India has published a patent application (202431005898 A) filed by Indian Association For The Cultivation Of Science, Kolkata, West Bengal, on Jan. 29, 2024, for 'bis-anthracene derived ligands and antibacterial compositions thereof.'
Inventor(s) include Dr. Jyotirmayee Dash; Dr. Ritapa Chaudhuri; Thumpati Prasanth; and Debasmita Biswas.
The application for the patent was published on Aug. 1, under issue no. 31/2025.
According to the abstract released by the Intellectual Property India: "Bis-anthracene derived ligands and antibacterial compositions thereof. Bis-anthracene derivative based ligands and method of synthesis thereof is provided for gene targeting including targeting G4s in the three genes (pmrA, hsdS and recD) in S. pneumoniae. The effects of these ligands in clinical isolates of multi-drug resistant (MDR) S. pneumoniae and other MDR pathogenic bacterial strains were investigated to find that the most potent ligand could be synthesized by bioorthogonal cycloaddition from its alkyne azide fragments in live bacterial cells, transformed with pmrA-G4 containing plasmid. A synergistic composition comprising antibiotic/s and bis-anthracene derived ligand/s with said ligands including selectively An4 ligand for co-operative enhanced antibiotic activity preferably of ciprofloxacin is also provided."
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