Intellectual Property India Publishes Patent Application for 'Chimeric Transgenic Immunoglobulin Mice With An Altered Heavy Chain Locus And Methods Of Making And Using Same' Filed by Gilead Sciences, Inc.

MUMBAI, India, Aug. 8 -- Intellectual Property India has published a patent application (202517070003 A) filed by Gilead Sciences, Inc., Foster City, U.S.A., on July 23, for 'chimeric transgenic immunoglobulin mice with an altered heavy chain locus and methods of making and using same.'

Inventor(s) include Rohrer, Daniel; and Brams, Peter.

The application for the patent was published on Aug. 8, under issue no. 32/2025.

According to the abstract released by the Intellectual Property India: "Chimeric transgenic immunoglobulin (Ig) mice are provided that comprise an altered heavy chain locus in which endogenous mouse D and J segments have been deleted and a human heavy chain Ig transgene is inserted at that location such that the transgenic Ig mouse expresses an antibody repertoire that utilizes human VH and mouse VH in heavy chains, each linked to human DH and JH segments, leading to enhanced diversity. Methods of preparing and using the transgenic animals (e.g., to raise antibodies) are also provided."

The patent application was internationally filed on Jan. 16, 2024, under International application No.PCT/US2024/011639.

Disclaimer: Curated by HT Syndication.