Intellectual Property India Publishes Patent Application for 'Compositions, Systems, And Methods For Regulation Of Hepatitis B Virus Through Targeted Gene Repression' Filed by Tune Therapeutics, Inc.

MUMBAI, India, May 30 -- Intellectual Property India has published a patent application (202517024338 A) filed by Tune Therapeutics, Inc., Seattle, on March 18, for 'compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression.'

Inventor(s) include Cosgrove, Brian; Congdon, Kendra; Dean, Jason; Gough, Veronica; Black, Joshua B.; and Jones, Britta.

The application for the patent was published on May 30, under issue no. 22/2025.

According to the abstract released by the Intellectual Property India: "Provided herein are epigenetic-modifying DNA-targeting systems, such as CRISPR-Cas/guide RNA (gRNA) systems, for the transcriptional repression of Hepatitis B viral (HBV) genes to promote a cellular phenotype that leads to the reduction of HBV infection. In some embodiments, the epigenetic-modifying DNA-targeting systems bind to or target a target site of at least one gene or regulatory element thereof in a Hepatitis B viral DNA sequence in cell. In some aspects, the provided systems relate to the transcriptional repression of one or more Hepatitis B viral gene and/or regulatory element thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example in repressing Hepatitis B viral replication and expression in connection with Hepatitis B infections."

The patent application was internationally filed on Aug. 18, 2023, under International application No.PCT/US2023/072525.

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