MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202611008965 A) filed by Dr. Mukesh Kumar Singh; Mr. Ashwanee Kumar Sahu; Mr. Yugal Kishor Rajput; Mr. Rajendra Kumar Sahu; Dr. Omprakash Sahu; Mr. Vikas Kumar Sahu; Ms. Dolly Yadu; Ms. Pratibha Jaiswal; Mr. Lokesh Kumar; and Mr. Amit Kumar, Moradabad, Uttar Pradesh, on Jan. 29, for 'development and evaluation nasal mucoadhesive gel using natural polymer.'
Inventor(s) include Dr. Mukesh Kumar Singh; Mr. Ashwanee Kumar Sahu; Mr. Yugal Kishor Rajput; Mr. Rajendra Kumar Sahu; Dr. Omprakash Sahu; Mr. Vikas Kumar Sahu; Ms. Dolly Yadu; Ms. Pratibha Jaiswal; Mr. Lokesh Kumar; and Mr. Amit Kumar.
The application for the patent was published on March 13, under issue no. 11/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to the development and evaluation of a nasal mucoadhesive gel formulation using natural polymers for enhanced intranasal drug delivery. The formulation comprises chitosan (0.5-2.0% w/v) and sodium alginate (0.5-1.5% w/v) as mucoadhesive agents, benzalkonium chloride as preservative, and purified water as vehicle. It exhibits a pH of 5.5-6.5, viscosity of 5,000-15,000 centipoise, and mucoadhesive strength of 0.25-0.50 Newtons, enabling nasal residence time exceeding four hours. The synergistic polymer combination enhances mucoadhesion through electrostatic interactions and hydrogen bonding. In vitro studies show sustained drug release over eight hours following Higuchi kinetics, while ex vivo studies demonstrate improved nasal permeation with a ratio of 1.51. Ciliotoxicity studies confirm formulation safety, offering a cost-effective and biocompatible nasal drug delivery system."
Disclaimer: Curated by HT Syndication.
