MUMBAI, India, July 25 -- Intellectual Property India has published a patent application (202311047066 A) filed by Birla Institute Of Technology & Science, Pilani, Rajasthan, on Jan. 12, 2024, for 'drug-eluting reservoir-loaded corneal device for poorly water-soluble drugs and a method for preparing the same.'
Inventor(s) include Nirmal J; and Shridula Sankar.
The application for the patent was published on July 25, under issue no. 30/2025.
According to the abstract released by the Intellectual Property India: "The present invention relates to a drug-eluting reservoir-loaded corneal device to improve the solubility, stability, bioavailability, and permeability of poorly water-soluble drugs and a method for preparing such drug-eluting reservoir-loaded corneal devices. The invention is based on loading poorly water-soluble drugs into nanocarriers and loading the same as a reservoir in a drug-eluting corneal device. The invention discloses the preparation of three reservoirs using resveratrol drug loaded on nanocarriers, namely, resveratrol-loaded nanomicelles, resveratrol-loaded nanocrystals, and hydroxypropyl--cyclodextrins resveratrol complex which are further characterized and loaded into the device. The fabrication of respective corneal devices, namely, resveratrol nanomicelles loaded corneal device (NM-CD), resveratrol nanocrystals loaded corneal device (NC-CD), and resveratrol hydroxypropyl--cyclodextrin loaded corneal device (HCD-CD) is performed using a 3D printing technique. The fabricated corneal devices can sustain the drug in the tear longer and enhance the permeation into the aqueous humor. Various studies show that the devices are safe, non-irritant, stable, and sterilized."
Disclaimer: Curated by HT Syndication.
