MUMBAI, India, Aug. 29 -- Intellectual Property India has published a patent application (202517075718 A) filed by Novartis Ag, Basel, Switzerland, on Aug. 8, for 'engineered ketoreductase polypeptides.'
Inventor(s) include Ye, Ning; Hardegger, Leo Albert; Hueber, Lukas Simon; Leemans Martin, Laura; Mann, Gregory; Peschke, Theo; Stanger, Frederic Valentin; Alvizo, Oscar; and Subramanian, Nandhitha.
The application for the patent was published on Aug. 29, under issue no. 35/2025.
According to the abstract released by the Intellectual Property India: "The present disclosure provides engineered ketoreductase enzymes having improved enzymatic activity including the ability of selectively reducing tert-butyl rel-(3aR,6aS)-5- oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate to tert-butyl rel-(3aR,5s,6aS)-5- hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes."
The patent application was internationally filed on Jan. 10, 2024, under International application No.PCT/IB2024/050231.
Disclaimer: Curated by HT Syndication.
