MUMBAI, India, March 13 -- Intellectual Property India has published a patent application (202621008810 A) filed by Mr. Kapil Kulkarni; Dr. Gitanjali Deokar; and Mets Institute Of Pharmacy, Bhujbal Knowledge City, Nashik, Maharashtra, on Jan. 29, for 'immediate -release lisinopril and extended-release carvedilol bilayer tablet for management of hypertension and heart failure.'
Inventor(s) include Mr. Kapil Kulkarni; Dr. Gitanjali Deokar; Mr. Mayur Sawant; Mrs. Yogita Shinde; and Ms. Vaishnavi Pathak.
The application for the patent was published on March 13, under issue no. 11/2026.
According to the abstract released by the Intellectual Property India: "Immediate -Release Lisinopril and Extended-Release Carvedilol Bilayer Tablet for Management of Hypertension and Heart Failure The present invention relates to a bilayer pharmaceutical tablet comprising an immediate-release layer of lisinopril hydrochloride in an amount from 2.5 mg to 40 mg and an extended-release layer of carvedilol phosphate in an amount from 3 mg to 25 mg, the immediate-release layer containing crospovidone 8 to 15% w/w as disintegrant and maize starch or microcrystalline cellulose 3 to 12% w/w as diluent, and the extended-release layer containing hydroxypropyl methylcellulose (HPMC K100M) 25 to 40% w/w and methacrylic acid copolymer 10 to 20% w/w as release-controlling polymers, both layers being sequentially compressed in a ratio of 1:2 to 1:3 on a bilayer rotary tablet press to obtain tablets of uniform hardness and inter-layer adhesion, the process involving wet granulation, drying at 50-70 C, optimization of polymer and disintegrant concentrations by Central Composite Design under Quality by Design principles, and optional coating with HPMC E5 and polyethylene glycol 400, the resulting tablets providing immediate lisinopril release within 30 minutes and controlled carvedilol release over 24 hours."
Disclaimer: Curated by HT Syndication.
