Intellectual Property India Publishes Patent Application for 'Improved Process For Preparation Of 1-(2,3,6-Tri Fluoro Phenyl) Acetone' Filed by Aarti Pharmalabs Limited

MUMBAI, India, Sept. 26 -- Intellectual Property India has published a patent application (202421021662 A) filed by Aarti Pharmalabs Limited, Vapi, Gujarat, on March 21, 2024, for 'improved process for preparation of 1-(2,3,6-tri fluoro phenyl) acetone.'

Inventor(s) include Mr. Narendra Jagannath Salvi; Dr. Bharatkumar Surendra Patravale; Mr. Jitendra Sambhaji Jadhav; and Mr. Jayesh Aakaram Kamble.

The application for the patent was published on Sept. 26, under issue no. 39/2025.

According to the abstract released by the Intellectual Property India: "The present invention relates to a process for preparation of of 1-(2,3,6-trifluorophenyl)propan-2-one of formula (I) including C-alkylation of 1,2,4-trifluorobenzene of formula (V) by reacting with epichlorohydrin of formula (VI) to form 2-chloro-1-(2,3,6-trifluorophenyl) ethanol of formula (IV); epoxidation of 2-chloro-1-(2,3,6-trifluorophenyl)ethanol of formula (IV) in presence of suitable base to form 2-(2,3,6-trifluorobenzyl)oxirane of formula (III); ring opening of 2-(2,3,6-trifluorobenzyl)oxirane of formula (III) in presence of a suitable reducing agent to form 1-(2,3,6-trifluorophenyl)-2-propanol of formula (II); and oxidation of 1-(2,3,6-trifluorophenyl)-2-propanol of formula (II)."

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