MUMBAI, India, Aug. 1 -- Intellectual Property India has published a patent application (202421006325 A) filed by Tata Consultancy Services Limited, Maharashtra, on Jan. 31, for 'method and system for identifying nucleomodulins indicative of altered gene expression.'
Inventor(s) include Bose, Chandrani; Korgaonkar, Sania Ghanashyam; Anand, Swadha; and Mande, Sharmila Shekhar.
The application for the patent was published on Aug. 1, under issue no. 31/2025.
According to the abstract released by the Intellectual Property India: "This disclosure relates generally to a method and system for indicating gene expression changes in the host through identification of a category of microbial effector proteins called 'Nucleomodulins' (NMs). State-of-the-art methods target to fix the impaired cellular functions due to altered gene expression or altered protein expression. However, targeting NMs which are bacterial effector proteins is not yet achieved. The disclosed method provides identification of NMs in the biological sample of the host. Further, the biological sample is analyzed to identify pre-defined set of NMs or an unknown NMs through a plurality of ways. On of the way include constructing and utilizing a knowledgebase comprising NMs identified through curated literature search engines known to cause altered gene expression. Further, functional annotation of the NMs is performed by computationally analysing the corresponding protein sequences. Finally, the NMs are targeted using a nuclear constructs for controlling altered gene expression."
Disclaimer: Curated by HT Syndication.
