Intellectual Property India Publishes Patent Application for 'Methods And Compositions For The Treatment Of Autosomal Dominant Polycystic Kidney Disease' Filed by Helex Inc.

MUMBAI, India, Sept. 26 -- Intellectual Property India has published a patent application (202421022312 A) filed by Helex Inc., Lewes De, U.S.A., on March 22, 2024, for 'methods and compositions for the treatment of autosomal dominant polycystic kidney disease.'

Inventor(s) include Chaudhuri, Poulami; Kalvakuntla, Rohini; Gaur, Neha; Kappagantu, Rakesh; Nishtala, Aniruddha; and Gupta, Yugantak Raj.

The application for the patent was published on Sept. 26, under issue no. 39/2025.

According to the abstract released by the Intellectual Property India: "Compositions for the treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD) are provided, in particular for targeted genomic or mRNA editing to treat ADPKD. The compositions comprise a nucleic acid encoding at least one guide RNA (gRNA) wherein the at least one gRNA is configured to hybridise with a region within a 3' untranslated region (UTR) of a PKD1 gene, optionally wherein the region is proximal to or within a miR-17 binding site. Removal or disruption of the miR-17 binding site reduces or eliminates miRNA-17 mediated suppression of expressed PKD1 mRNA within target cells of the kidney thereby treating ADPKD."

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