MUMBAI, India, Jan. 23 -- Intellectual Property India has published a patent application (202521123327 A) filed by Dr. Nagaraju Bandaru, Nashik, Maharashtra, on Dec. 7, 2025, for 'neuroprotective mechanisms of sapindus laurifolia: a natural approach to brain protection.'
Inventor(s) include Dr. Nagaraju Bandaru; Dr. Pydiraju Kondrapu; Mrs. C. Shilpaja; Dr. Amareswarapu V Surendra; Mrs. Ch. Hanisha; Mrs. M. Jhansi Rani; Mr. Thulasee Nadh Reddy; Dr. Durishetty Soujanya; Dr. Roja Pathakota; and Jyothi Muddagoni.
The application for the patent was published on Jan. 23, under issue no. 04/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to the extraction and use of bioactive compounds from Sapindus laurifolia (soapnut) fruit kernels for neuroprotective and antioxidant applications. Specifically, the invention discloses a method for isolating MESL Fraction A from Sapindus laurifolia fruit kernel extract, enriched in flavonoids and polyphenolic compounds. This fraction demonstrates significant neuroprotective activity, reducing oxidative stress and improving cognitive function in preclinical models of neurodegenerative diseases, including Alzheimer's disease. The MESL Fraction A is shown to enhance the activity of key antioxidant enzymes, such as glutathione, superoxide dismutase (SOD), and catalase, while also inhibiting acetylcholinesterase activity, a key marker in Alzheimer's. The invention provides pharmaceutical compositions containing MESL Fraction A for the treatment or prevention of cognitive dysfunction and other neurodegenerative conditions, offering a novel, natural therapeutic strategy targeting oxidative stress and neuroinflammation in the brain."
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