MUMBAI, India, July 25 -- Intellectual Property India has published a patent application (202517044006 A) filed by Martin-Luther-Universitat Halle-Wittenberg, Halle, Germany, on May 6, for 'nucleic acid active agents against various plant pathogens.'

Inventor(s) include Ghasemzadeh, Aysan; Knoblich, Marie; Behrens, Sven-Erik; Gago-Zachert, Selma Persida; and Gursinsky, Torsten.

The application for the patent was published on July 25, under issue no. 30/2025.

According to the abstract released by the Intellectual Property India: "The invention relates to newly identified nucleic acids, ribonucleic acids (RNAs) and deoxyribonucleic acids (DNAs), specifically esiRNAs/ERNAs (effective small interfering RNAs) and RNAs derived therefrom, as well as eASO (effective antisense DNA oligonucleotides), collectively referred to as eNAs (effective nucleic acids), which are used in RNA silencing/RNAi or RNA silencing/antisense methods, as active agents against various variable plant pathogens. To identify the eNAs, a screening method, hereinafter also referred to as "eNA screen", was applied for the first time in standardised form to objective (target) RNAs of various plant pathogens. As a result, a new class of these active agents against these pathogens was identified and successfully used against them. The invention further relates to the construction of double-stranded ribonucleic acids, edsRNAs (effectively active double-stranded RNAs), which contain nucleotide sequences of identified esiRNAs/ERNAs or related RNAs derived therefrom, and which can be successfully used in the RNA silencing/RNAi methods as active agents in plant protection against these same variable plant pathogens*."

The patent application was internationally filed on Nov. 07, 2023, under International application No.PCT/EP2023/080990.

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