MUMBAI, India, July 11 -- Intellectual Property India has published a patent application (202521060273 A) filed by Mr. Rahul Yuvraj Pagar, Malegaon, Maharashtra, on June 24, for 'pharmaceutical composition of nicardipine in a lyophilized dry emulsion form and its dosage form thereof.'
Inventor(s) include Mr. Rahul Yuvraj Pagar; and Dr. Avinash Balasaheb Gangurde.
The application for the patent was published on July 11, under issue no. 28/2025.
According to the abstract released by the Intellectual Property India: "The present invention relates to a novel lyophilized dry emulsion formulation of Nicardipine (OLDE-N) designed to enhance its solubility, stability, and oral bioavailability. Nicardipine, a calcium channel blocker, suffers from poor aqueous solubility, limiting its therapeutic efficacy when administered orally. This invention addresses this challenge by employing a carefully optimized oil-in-water emulsion system, incorporating Caprylic Capric Triglyceride as the oil phase, Tween 80 and Transcutol HP as surfactant and co-surfactant respectively, maltodextrin as a cryoprotectant, and sodium alginate as a stabilizer. The emulsion is developed based on pseudo-ternary phase diagrams and optimized using Design Expert software for maximal drug solubility and formulation stability. The emulsion is subjected to freeze-drying (lyophilization) to obtain a free-flowing dry powder suitable for direct compression into tablets. Tablets containing 20 mg Nicardipine are prepared using OLDE-N with PVP K30 as a binder, resulting in robust tablets with consistent drug content, rapid disintegration, and enhanced dissolution rates. Comprehensive characterization including solubility, flow properties, hardness, friability, and in vitro dissolution confirms the improved pharmaceutical performance of the formulation. This invention provides an efficient and scalable approach to formulate poorly soluble Nicardipine into a patient-friendly oral dosage form with superior bioavailability and stability."
Disclaimer: Curated by HT Syndication.
