MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202611048554 A) filed by Mr. Himank Varshney; Mr. Ajeet Singh; Mr. Sukh Pal Kashyap; Mr. Ammu Pratap Singh; Mr. Anil Kumar; Ms. Ekta Upadhyay; and Mr. Mukul Kumar, Moradabad, Uttar Pradesh, on April 16, for 'phytochemical screening and antiurolithiatic activity of tagetes erecta in experimental model.'
Inventor(s) include Mr. Himank Varshney; Mr. Ajeet Singh; Mr. Sukh Pal Kashyap; Mr. Ammu Pratap Singh; Mr. Anil Kumar; Ms. Ekta Upadhyay; and Mr. Mukul Kumar.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to phytochemical screening and antiurolithiatic activity of Tagetes erecta Linn. leaves evaluated through in vitro and in vivo experimental models. Chloroform and aqueous leaf extracts prepared by Soxhlet extraction and cold maceration respectively were screened for secondary metabolites including flavonoids, saponins, and phenolic compounds. Both extracts demonstrated significant antioxidant activity with IC50 values of 64.17 and 72.6 micrograms per millilitre in DPPH assay respectively. In vitro calcium oxalate crystallization studies revealed significant reduction in crystal size by aqueous extract to 7.9 micrometres and chloroform extract to 8.2 micrometres. In vivo studies using 0.75 percent ethylene glycol-induced urolithiasis in Wistar rats at one hundred milligrams per kilogram dose demonstrated significant reduction in urinary calcium, oxalate, and phosphate, with normalization of magnesium levels. Histopathological analysis confirmed reduced crystal deposition and restoration of renal architecture. The invention provides a scientifically validated herbal therapeutic for kidney stone prevention and management."
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