MUMBAI, India, July 11 -- Intellectual Property India has published a patent application (202521059945 A) filed by Ms. Rutuja Dattatray Chougale, Kolhapur, Maharashtra, on June 23, for 'phytoconstituents of limonia acidissima extract in topical cream composition and its anti-cancer potential thereof.'

Inventor(s) include Ms. Rutuja Dattatray Chougale; Ms. Sayali Nandkumar Anugade; Ms. Akanksha Rajaram Patil; Ms. Samiksha Shantaram Biraje; Ms. Supriya Santosh Mhetar; Ms. Madhura Narayan Dhongade; Ms. Shrejal Bajirao Patil; and Mr. Ashish Khanderao Patil.

The application for the patent was published on July 11, under issue no. 28/2025.

According to the abstract released by the Intellectual Property India: "The present invention relates to a novel, plant-based therapeutic approach for the management and supportive care of melanoma, utilizing bioactive compounds derived from Limonia acidissima (wood apple). The invention integrates computational and pharmaceutical techniques to identify, evaluate, and formulate a topical cream incorporating phytoconstituents from this medicinal plant. Initially, phytochemicals were mined from public databases and screened for their melanoma-relevant biological targets using molecular docking and network pharmacology approaches. Key protein targets and pathways, particularly those involved in inflammation and cancer progression, were identified through STRING, GeneCards, and KEGG analyses. ADMET profiling ensured the drug-likeness and safety of selected compounds. The active extract was prepared via Soxhlet extraction, followed by solvent evaporation and phytochemical screening. A stable, skin-compatible cream was then formulated using hydrated polymers and excipients, with the Limonia acidissima extract incorporated to create a homogenous system. The cream was evaluated using FTIR, GC-MS, DSC, and standard pharmaceutical tests such as pH, spreadability, and drug content uniformity. The invention effectively correlates in silico therapeutic potential with a practical dermal formulation, offering a safe, affordable, and natural solution for melanoma-related skin conditions. This integrative approach bridges traditional knowledge with modern science for translational dermatological innovation."

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