MUMBAI, India, May 30 -- Intellectual Property India has published a patent application (202517044000 A) filed by Merck Sharp & Dohme Llc, Rahway, U.S.A., on May 6, for 'preparation of pyrazolopyridine and triazolopyridine derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors.'
Inventor(s) include Lim, Yeon-Hee; Hugelshofer, Cedric Lorenz; Metwally, Essam; Roane, James P.; and Shockley, Samantha E.
The application for the patent was published on May 30, under issue no. 22/2025.
According to the abstract released by the Intellectual Property India: "Provided are compounds of Formula I, Formula Ib or Formula Ic and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, Formula Ib or Formula Ic, pharmaceutical compositions comprising compounds of Formula I, Formula Ib or Formula Ic, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I to a patient in need thereof."
The patent application was internationally filed on Oct. 26, 2023, under International application No.PCT/US2023/077842.
Disclaimer: Curated by HT Syndication.
