MUMBAI, India, July 5 -- Intellectual Property India has published a patent application (202517057063 A) filed by Boehringer Ingelheim International Gmbh, Ingelheim am Rhein, Germany, on June 13, for 'processes and intermediates for the preparation of spirocyclic kras inhibitors.'
Inventor(s) include Zhang, Yongda; Chong, Eugene; Lei, Zhen; Reeves, Jonathan Timothy; and White, Jada A. H.
The application for the patent was published on July 4, under issue no. 27/2025.
According to the abstract released by the Intellectual Property India: "This invention relates to an efficient and enantioselective synthesis of the spiro-compounds of formula (1) as common intermediate, featuring an asymmetric introduction of the all-5 carbon quaternary centre in high selectivity and a very efficient one-pot procedure for the C2 elongation to generate the spiro-structure. For the all-carbon quaternary centre, a Tsuji-Trost asymmetric allylic alkylation (AAA) process was designed to develop a sustainable procedure with very low catalyst loading, thereby also facilitating the Pd content control in the product, under practically solvent free conditions. Furthermore, multiple synthetic transformations in a one-pot procedure were implemented by using a one-pot procedure either in form of a three-transformation sequence comprising Hydroboration-Alkylation-Dieckmann Condensation to compound of formula (1) or in form of a five-transformation sequence comprising Hydroboration-Alkylation-Dieckmann Condensation-Hydrolysis-Decarboxylation to compound of formula (9)."
The patent application was internationally filed on Nov. 29, 2023, under International application No.PCT/EP2023/083453.
Disclaimer: Curated by HT Syndication.
