MUMBAI, India, Jan. 23 -- Intellectual Property India has published a patent application (202521125146 A) filed by Dr. D. Y. Patil Institute Of Pharmaceutical Sciences And Research; School Of Pharmacy And Research; and Dr. Harshad S Kapare, Pune, Maharashtra, on Dec. 11, 2025, for 'quercetin loaded polymeric nanosponge's cream for wound healing.'
Inventor(s) include Dr. Harshad S Kapare; Mr. Pawan N. Karwa; Dr. Ritesh P. Bhole; and Dr. Sonali D. Labhade.
The application for the patent was published on Jan. 23, under issue no. 04/2026.
According to the abstract released by the Intellectual Property India: "Quercetin's therapeutic efficacy is limited by its poor solubility. This study aimed to enhance the solubility, permeation, and effectiveness of quercetin by formulating it into nanosponges loaded topical cream. Methods: Quercetin nanosponges were prepared using the emulsion solvent diffusion method and optimized based on particle size, SEM analysis, entrapment efficiency, FT-IR, DSC, and in vitro studies. The optimized nanosponges were then incorporated into a topical cream formulation and evaluated through cream characterization, ex-vivo, and in vivo studies. Results: The optimized nanosponges exhibited a particle size of 238 nm and zeta potential of -29 mV. SEM analysis revealed a sponge-like structure, and entrapment efficiency was measured at 64.8%. In vitro release studies demonstrated 86.8% drug release over 24 hours. The prepared nano cream showed homogeneity, and ex-vivo skin permeation studies indicated 94.3% permeation over 5 hours, with quercetin-loaded nanosponges showing significantly higher efficiency compared to the standard cream. Pharmacokinetic and pharmacodynamic evaluations demonstrated superior efficacy of quercetin-loaded nanosponges compared to marketed formulations."
Disclaimer: Curated by HT Syndication.
