MUMBAI, India, Nov. 14 -- Intellectual Property India has published a patent application (202517095271 A) filed by Cytiva Sweden Ab, Uppsala, Sweden, on Oct. 3, for 'spacers for gene expression constructs.'
Inventor(s) include Jonsson, Andreas; and Ivansson, Daniel.
The application for the patent was published on Nov. 14, under issue no. 46/2025.
According to the abstract released by the Intellectual Property India: "The invention provides a nucleic acid sequence comprising a modified CTCF-binding sequence represented by: TGCAGTACCTCCCTN1N2N3CCAGCAGGN4GGCAN5N6AGN7GAAN8GGTGAACTGGAGT (SEQ ID NO: 10) wherein N1, N2, N3, and N5 each independently is C or G; N4 is T or G; N6 and N7 each independently is C or T; and N8 is T or A. Each of N1 to N8 represents a nucleic acid substitution at a corresponding locus on the CTCF-binding site (SEQ ID NO: 1) of the wild-type chicken Hypersensitivity Site 4 (cHS4) insulator. Provided are also expression vectors and recombinant cells incorporating the modified CTCF-binding sequence, and an associated method of producing at least two polypeptides."
The patent application was internationally filed on Mar. 27, 2024, under International application No.PCT/EP2024/058187.
Disclaimer: Curated by HT Syndication.
