MUMBAI, India, Feb. 27 -- Intellectual Property India has published a patent application (202531003183 A) filed by Indian Institute Of Technology, Kharagpur, West Bengal, on Jan. 14, 2025, for 'specialized single stranded oligonucleotide probes for the rapid detection of rifampicin-resistant tuberculosis (rr-tb).'
Inventor(s) include Sankhla, Arjun; and Bosedasgupta, Dr. Somdeb.
The application for the patent was published on Feb. 27, under issue no. 09/2026.
According to the abstract released by the Intellectual Property India: ""SPECIALIZED SINGLE-STRANDED OLIGONUCLEOTIDE PROBES FOR THE RAPID DETECTION OF RIFAMPICIN-RESISTANT TUBERCULOSIS (RR-TB)" provided are specialized single-stranded oligonucleotide probes for rapid detection of rifampicin-resistant tuberculosis (RR-TB) using an easy analyte generation protocol and a novel hybridization buffer. The present disclosure relates to two highly specific, specialized oligonucleotide probes, containing several nucleotides with methylene bridge between 2'-oxygen and 4'-carbon of ribose sugar (Locked conformation) alongside DNA nucleotides, for the detection of these rifampicin resistance-specific mutations in Mycobacterium tuberculosis (Mtb). The probes can easily be used for detection using any fluorometer which can measure fluorescence anisotropy and/or by using any other technique which can detect Probe-DNA hybridization. Moreover, looking at the future scope of this disclosure, these probes can easily be incorporated into any kind of low-cost and non-invasive diagnostics kit like electrochemical biosensors for the rapid detection at POC settings using a portable potentiostat."
Disclaimer: Curated by HT Syndication.
