MUMBAI, India, Jan. 23 -- Intellectual Property India has published a patent application (202511129165 A) filed by Maharishi Markandeshwar, Ambala, Haryana, on Dec. 19, 2025, for 'synthesis of 8-ethyl-5-oxo-2-(4-[2-phenyl)-2-oxoethyl]-1-piperazinyl)-5,8-dihydropyrido[2,3- d]pyrimidine-6 carboxylic acids as potential antibacterial agents.'
Inventor(s) include Prof. Dinesh K. Mehta; Vishal Sharma; Prof. Rina Das; and Diksha Sharma.
The application for the patent was published on Jan. 23, under issue no. 04/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to synthesise 8-ethyl-5-oxo-2-(4-[2-phenyl)-2-oxoethyl]-1-piperazinyl)-5,8-dihydropyrido[2,3-d] pyrimidine-6-carboxylic acids as Potential Antibacterial Agents. A novel series of (E)-8-ethyl-2-(4-(2-(hydroxyimino)-4-substituted-phenyl)-piperazin-1-yl)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives DV1-DV5 have been designed and synthesized. The target compounds were investigated for their antibacterial activity against gram positive (Staphylococcus aureus, ATCC 25923, Enterococcus faecalis, ATCC 29212) and gram negative bacterium (Escherichia coli, ATCC 25922, Pseudomonas aeruginosa, ATCC 27853), respectively. The oxime functionality was introduced at C-2 position of pipemidic acid derivatives. The structure of synthesized derivatives was confirmed by IR, 1H NMR and Mass spectrometry techniques. Among the tested compounds, (DV1, DV2, DV3, DV4 & DV5) revealed potent antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa bacterial strains with MICs range of 9-40 g/mL, against the tested bacterial strains."
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