Intellectual Property India Publishes Patent Application for 'System And Method To Determine Candidate Residues For Thermostable Mutations' Filed by Apratima Biosolutions Pvt. Ltd.

MUMBAI, India, Sept. 5 -- Intellectual Property India has published a patent application (202441010189 A) filed by Apratima Biosolutions Pvt. Ltd., Bengaluru, Karnataka, on Feb. 14, 2024, for 'system and method to determine candidate residues for thermostable mutations.'

Inventor(s) include Roy Rohit; and Manjunath Kavyashree.

The application for the patent was published on Sept. 5, under issue no. 36/2025.

According to the abstract released by the Intellectual Property India: "The present disclosure discloses a method to determine candidate residues for thermostable mutations. The method includes receiving molecular dynamics simulation data of the protein at a plurality of temperature points to extract frame-wise inter-residue distance matrices of one or more residues. The method also includes generating residue-specific dataset for each residue by extracting corresponding row in each matrix of the derived distance matrices. Furthermore, the method includes classifying the generated residue-specific datasets into a low temperature simulation data and a high simulation data. The method also includes calculating contribution of each residue toward unfolding of the protein based on the classification of the generated residue-specific datasets. Thereafter, the method includes ranking the one or more residues based on the calculated contribution to unfolding of the protein to determine candidate residues thermostable mutations."

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