MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202641083794 A) filed by Nitte Meenakshi Institute Of Technology, Nitte Deemed To Be University, Bengaluru; Nitte College Of Pharmaceutical Sciences, Nitte Deemed To Be University, Bengaluru; Dr. K Kavitha; Mrs. Vidyashree N H; Dr. V. Kusum Devi; and Mr. Ziaul Karim on July 08, 2026, for A Chronomodulated Pulsatile Pulsincap Drug Delivery System Comprising Tramadol Hydrochloride For Circadian Management Of Arthritic Pain.
Inventors include Nitte Meenakshi Institute Of Technology, Nitte Deemed To; Nitte College Of Pharmaceutical Sciences, Nitte Deemed To; Dr. K Kavitha; Mrs. Vidyashree N H; Dr. V. Kusum Devi; and Mr. Ziaul Karim.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: ABSTRACT OF THE INVENTION Title: A Chronomodulated Pulsatile Pulsincap Drug Delivery System Comprising Tramadol Hydrochloride for Circadian Management of Arthritic Pain The present invention relates to a chronomodulated pulsatile drug delivery system designed to synchronize Tramadol release with biological rhythms for circadian management of arthritic pain. The system comprises drug-loaded microcapsules (100) with Tramadol HCl (110) and Eudragit polymers (120); a modified pulsincap device (200) with cross-linked capsule body (210), HPMC hydrogel plug (220) for 2-3 hour lag time, and enteric coating (230) with cellulose acetate phthalate; chronotherapeutic release mechanism (300); circadian alignment (400) for bedtime administration with early morning release; and therapeutic benefits (500). The invention provides reduced dosing frequency, enhanced patient compliance, and optimized therapeutic efficacy by synchronizing drug release with peak arthritic pain patterns.
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