MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202641123602 A) filed by Dumala Naresh; Srilekha Chintala; and Koneru Lakshmaiah Education Foundation Klef on October 15, 2026, for A Method For Assessing Combined Microplastic And Nanoplastic Genotoxicity Using A Multi- Biomarker Panel.
Inventors include Srilekha Chintala; Dumala Naresh; and Kakarla Ramakrishna.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention relates to a method for assessing genotoxicity induced by combined exposure to polystyrene microplastics (PS-MPs) and polystyrene nanoplastics (PS-NPs). The method comprises exposing a biological system to PS-MPs, PS-NPs, or combinations (PS-MPs+PS-NPs) thereof, collecting biological samples comprising peripheral blood leukocytes, bone marrow cells, liver cells, and kidney cells, and evaluating DNA damage using an alkaline comet assay. Genotoxicity is determined by measuring one or more comet assay parameters selected from percentage tail DNA, tail length, tail moment, and olive tail moment. The obtained DNA damage responses are integrated to assess and classify the genotoxic potential associated with individual and combined particle exposures. The method enables identification of enhanced genotoxic effects arising from mixed-particle exposure and provides a standardized approach for biological monitoring, environmental toxicology, nanotoxicology, and risk assessment of pollutants and contaminants.
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