MUMBAI, India, July 30 -- Intellectual Property India has published a patent application (202641087551 A) filed by Vinayaka Mission'S Research Foundation Deemed To Be University; and , Ariyanoor, Salem -; Tamil Nadu, India. Salem Tamil Nadu India on July 17, 2026, for A Method For Biosynthetic Fucoidan Derivatives As Neuroprotective Therapeutic Agents.
Inventors include Arul Balasubramanian; Anbazhagan Venkattappan; Kothai Ramalingam; Yamuna Annadurai; and Nagappan Andiappan.
The application for the patent was published on July 24, 2026, under issue no. 30/2026.
Abstract: The present invention discloses a method for biosynthetic fucoidan derivative synthesis and neuropharmacological evaluation for neuroprotection against neurodegenerative diseases. Fucoidan monomer is isolated from Sargassum marginatum through ion exchange chromatography, mild acid hydrolysis, and gel permeation chromatography. Acetylated, benzoylated, and phosphorylated derivatives are synthesized at C3 and C4 hydroxyl positions and confirmed by UV, ATR- FTIR, 1HNMR, and mass spectroscopy. In-silico docking against Acetylcholinesterase, beta-secretase 1, and Glycogen synthase kinase-3beta with MM-GB/SA binding free energy analysis identifies phosphorylated fucoidan as the optimal derivative. In-vitro evaluation in Neuro-2A cells demonstrates superior neuroprotective efficacy through restored cell viability, acetylcholinesterase inhibition, dopamine restoration, enhanced antioxidant activity, preserved mitochondrial integrity, suppressed apoptosis, and upregulated BDNF, Nrf2, and Bcl-2 expression, providing a promising marine-derived lead candidate for neurodegenerative disease management.
Disclaimer: Curated by HT Syndication.
