MUMBAI, India, June 22 -- Intellectual Property India has published a patent application (202641068603 A) filed by Krupanidhi College Of Pharmacy; and Nimisha Jain on June 01, 2026, for A Method For Thermo-Responsive Oral In-Situ Gel Delivery.
Inventors include Nimisha Jain; Preethi Sudheer; and Mallikarjun.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: The present invention discloses a thermo-responsive oral in-situ gel composition comprising curcumin and ketorolac configured for localized management of oral mucositis. Curcumin is incorporated in the form of a cyclodextrin inclusion complex to improve aqueous solubility, stability, and release characteristics. The formulation further comprises thermo-responsive polymers and mucoadhesive agents configured to transition from a low-viscosity liquid state into a bioadhesive gel upon exposure to physiological temperature conditions within the oral cavity. The gel system provides prolonged mucosal retention, sustained release of therapeutic agents, and reduced systemic exposure to ketorolac. Curcumin provides antioxidant and anti-inflammatory activity while ketorolac provides analgesic action for symptomatic relief of oral mucositis associated with chemotherapy and radiotherapy treatments. The invention improves therapeutic efficacy, patient compliance, localized drug delivery, and prolonged oral mucosal protection through controlled thermo-responsive pharmaceutical gelation technology.
Disclaimer: Curated by HT Syndication.
