MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202641123777 A) filed by Vels Institute Of Science, Technology And Advanced Studies Vistas on October 15, 2026, for A Phytochemical Composition And Method For Selective Apoptosis-Mediated Anticancer Activity Against Colon Cancer.
Inventors include B. Usharani; and Deepika V.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: Disclosed is a phytochemical composition for anticancer application against human colon cancer cells. The phytochemical composition comprises a methanolic extract derived from rhizomes of Drynaria quercifolia and includes plant-derived bioactive phytochemical constituents characterized by Gas Chromatography-Mass Spectrometry and Liquid Chromatography-Mass Spectrometry. The phytochemical composition exhibits selective cytotoxic activity against HCT-116 human colon cancer cells while exhibiting reduced cytotoxicity toward 3T3-L1 normal cells. The selective cytotoxic activity is associated with an apoptosis-mediated anticancer mechanism characterized by apoptotic cellular response detectable through Annexin V/PI flow cytometry, modulation of expression of apoptosis-associated genes comprising Bax, Bcl-2, Cytochrome c, and Caspase-3, and DNA fragmentation associated with apoptotic cell death. The identified phytochemical constituents are correlated with the selective cytotoxicity and apoptosis-mediated anticancer response, thereby providing a plant-derived composition having potential for further pharmaceutical development against human colon cancer.
Disclaimer: Curated by HT Syndication.
