MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202548008754 A) filed by Genomatica, Inc. on February 03, 2025, for Aldehyde Dehydrogenase Variants And Methods Of Use.
Inventors include Hoff, Kevin; Tracewell, Cara Ann; Chan, Kui Number; Shah, Amit; Warner, Joseph; and Noble, Michael Filed On.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3- hydroxybutyraldehyde (3- HBal) and/or 1,3 -butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additionaly provides methods for producing 4- hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention also relates to a method for producing 3- hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising providing a substrate to the polypeptide as disclosed and converting the substrate to 3-HBal and/or 1,3-BDO.
Disclaimer: Curated by HT Syndication.
