MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202611107718 A) filed by Maharishi Markandeshwar Deemed To Be University on September 05, 2026, for An Rp-Hplc-Based Method For Simultaneous Stability Assessment And Quantitative Determination Of Metoprolol Succinate In Controlled-Release Formulations.
Inventors include Rahul Kumar; Dr. Vipin Saini; Dr. Sumeet Gupta; Deepa Rani; Dr. Manisha Bhatia; Kartik Kansay; Dishant Saini; Himanshu Rana; Amit Mittal; Preeti Garg; Varsha Chauhan; and Ankur Gupta.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention relates to a simple, rapid, accurate, precise, robust, and stability-indicating reverse-phase high-performance liquid chromatographic (RP-HPLC) method for the quantitative estimation of metoprolol succinate in controlled-release tablet formulations. The method is particularly suitable for formulations containing natural and synthetic polymers and provides effective separation of metoprolol succinate from formulation excipients, polymeric matrix components, and potential degradation products. The invention employs optimized chromatographic conditions comprising a C-8 analytical column, a buffer-acetonitrile mobile phase, and ultraviolet detection to achieve reliable peak resolution, reproducible retention time, and accurate quantification of the active pharmaceutical ingredient. The method has been validated in accordance with ICH guidelines and demonstrates satisfactory specificity, linearity, accuracy, precision, robustness, sensitivity, and system suitability. The developed analytical procedure is suitable for routine pharmaceutical quality control, assay determination, dissolution testing, stability studies, and formulation development of metoprolol succinate controlled-release tablets. The method offers advantages including reduced analysis time, simplified sample preparation, high reproducibility, cost-effectiveness, and freedom from interference by formulation excipients and polymeric materials. Accordingly, the invention provides a reliable analytical tool for the evaluation and quality assurance of metoprolol succinate controlled-release pharmaceutical products.
Disclaimer: Curated by HT Syndication.
