MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202641084559 A) filed by Koneru Lakshmaiah Education Foundation on July 09, 2026, for Biology-Constrained Temporal Multimodal Graph Transformer For Hematologic Malignancy Risk Stratification.
Inventors include G. Chinna Pullaiah; and Dr. P. M. Ashok Kumar.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present invention discloses a biology-constrained temporal generative multimodal graph-transformer system and method for risk stratification and clinical decision support in hematologic malignancies. The system receives heterogeneous biomedical data comprising multi-omics, whole-slide pathology images, clinical narrative data, flow cytometry, laboratory information, and electronic health records. The data are transformed into unified token representations, integrated through a heterogeneous biological interaction graph using relation-aware graph reasoning, and processed by a temporal transformer to model longitudinal disease progression. A probabilistic missing-modality inference framework estimates latent representations for incomplete observations and generates uncertainty-aware predictions. A multi-task prediction engine produces disease risk, molecular subtype, relapse, survival, and prognosis predictions, followed by probability calibration to improve predictive reliability under incomplete multimodal clinical data.
Disclaimer: Curated by HT Syndication.
