MUMBAI, India, June 24 -- Intellectual Property India has published a patent application (202411089701 A) filed by Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act Act Xxi Of on November 19, 2024, for C-17 Substituted 14-Deoxy-11,12-Didehydroandrographolide Compound As A Potential Anti-Viral Agent And Process For Preparation Thereof.
Inventors include Gulshan Kumar; Shazia Choudhary; Bhupesh Kumar Sharma; Alna Kuriyickal Martin; Yogesh Sardana; Renuga Devi; Bokara Kiran Kumar; Manzoor Ahmed; Sanket Kumar Shukla; Qazi Naveed Ahmed; Ravi Shankar; and Zabeer Ahmed.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: The present invention provides substituted 14-deoxy-11,12-didehydroandrographolide (14-DDA) compounds. The present invention particularly provides substituted 14-deoxy-11,12-didehydroandrographolide (14-DDA) compounds having substitutions formed to the exocyclic C8-17 double bond. The present invention also provides their method of preparation, pharmaceutical compositions thereof and their use as anti-viral agents. In comparison the parent molecule andrographolide (90% viral reduction), B1 and B8 show more than 90% viral reduction at all three concentrations in the preliminary screening, they were taken for further studies to determine their EC50. Upon analysis, the EC50 for B1 and B8 were obtained 0.329µM and 0.153µM respectively.
Disclaimer: Curated by HT Syndication.
