MUMBAI, India, Oct. 12 -- Intellectual Property India has published a patent application (202611103477 A) filed by Nims University Rajasthan, Jaipur on August 27, 2026, for Composition For Ototoxicity-Reduced Pulmonary Drug Delivery.
Inventors include Krishna Mittal; Ruchika Goyal; Dr. Anurag Kumar Singh; Dr. Sachin Kumar; Dr. Prashant Nakash; and Dr. Sagar Pareek.
The application for the patent was published on October 09, 2026, under issue no. 41/2026.
Abstract: The present invention relates to a microencapsulated pharmaceutical composition for ototoxicity-reduced pulmonary drug delivery. The composition comprises a core comprising at least one respiratory agent, a biodegradable polymeric matrix encapsulating the core, and an otoprotective layer comprising at least one otoprotective agent. The respiratory agent comprises aminoglycoside antibiotics, corticosteroids, bronchodilators, or combinations thereof, while the otoprotective agent comprises antioxidants, free radical scavengers, NMDA receptor antagonists, or combinations thereof. The biodegradable polymeric matrix comprises Poly(lactic-co-glycolic acid) (PLGA), chitosan, sodium alginate, polycaprolactone, gelatin, or combinations thereof. The composition further comprises porous inhalable microparticles exhibiting optimized aerodynamic characteristics suitable for deep lung deposition and sustained pulmonary release. The invention additionally discloses a manufacturing method comprising preparation of an organic phase, formation of a primary emulsion and double emulsion, solvent evaporation, and spray drying to obtain inhalable porous microparticles.
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