MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202611062217 A) filed by Jawaid Ahmad Khan; Rahmat Khan; Ankit Singh; and Masnad Khan on May 16, 2026, for Compositions And Methods For Crispr/Cas9-Mediated Viral Resistance In Cotton.
Inventors include Jawaid Ahmad Khan; Rahmat Khan; Ankit Singh; and Masnad Khan.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present invention relates to the development of a CRISPR-Cas9 genome editing system to confer resistance against Cotton leaf curl Multan virus (CLCuMuV) inducing cotton leaf curl disease (CLCuD) in G. hirsutum cultivar HS6. The invention discloses the design and cassette of multiplex single guide RNA (sgRNA) cassette targeting overlapping (C1/C4) regions of CLCuMuV in sense and antisense orientations. Transgenic cotton plants, cells, or tissues expressing the CRISPR-Cas9 system are generated through Agrobacterium-mediated transformation. Upon viral inoculation, the Cas9/sgRNA complex induces site-specific double-strand breaks (DSBs) in the viral DNA, leading to disruption of viral replication. The invention provides a durable genome-editing-based strategy for the developing begomovirus-resistant cotton cultivar and establishes a broadly applicable antiviral platform for crop improvement.
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