MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202531003109 A) filed by National Institute Of Pharmaceutical Education And Research, Guwahati on January 14, 2025, for Compounds For Human Antigen R (hur) Rna Binding Protein Inhibition And Method Of Preparation Thereof.
Inventors include Kalyan Kumar Sethi; Purusottam Mohapatra; Subarna Jyoti Kalita; Omkar Palker; Mayur Arun Pawar; Anurag Saini; Saumya Ranjan Badajena; Satyajit Laxman Murkute; Sujoy Bhowmik; Veena K S; Sanjay Kumar; Kumari Kaushiki; and Juhi Dey.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: TITLE: COMPOUNDS FOR HUMAN ANTIGEN R (HuR) RNA BINDING PROTEIN INHIBITION AND METHOD OF PREPARATION THEREOF Abstract The present invention relates to compounds with structure as illustrated in formula I and their synthesis. The synthesised compounds demonstrate inhibitory activity against Human Antigen R (HuR) RNA binding proteins and thereby anticancer activity. The synthesised compounds are relevant for hyperproliferative diseases that have HuR overexpression. Formula I Wherein- R1 is selected from a group comprising hydrogen and chlorine; R2 is selected from a group comprising phenylmethanamine, 2- phenylethanamine, propan-2-amine, piperidine, (4-fluorophenyl)methanamine, butan-1-amine, (3- bromophenyl)methanamine, p-tolylmethanamine and (4-chlorophenyl)methanamine and R3 is selected from a group comprising naphthalene-1,4-dione and anthracene-1,4-dione.
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