MUMBAI, India, July 30 -- Intellectual Property India has published a patent application (202641087867 A) filed by Vellore Institute Of Technology on July 17, 2026, for Computational Method For Identifying Therapeutic Targets And Candidate Compounds For Diabetic Nephropathy.
Inventors include Devi Rajeswari V; and Soumik.
The application for the patent was published on July 24, 2026, under issue no. 30/2026.
Abstract: ABSTRACT COMPUTATIONAL METHOD FOR IDENTIFYING THERAPEUTIC TARGETS AND CANDIDATE COMPOUNDS FOR DIABETIC NEPHROPATHY A computer-implemented method for identifying a therapeutic target and a candidate compound for diabetic nephropathy comprises obtaining gene expression data (100) from a transcriptomic database, ferroptosis-associated gene data (102) from a ferroptosis gene database, disease-associated gene data (104) from a disease gene database, and oxidative stress gene data (106) from an oxidative stress gene database. The method comprises performing an intersection analysis (108) of the gene expression data (100), ferroptosis-associated gene data (102), disease-associated gene data (104), and oxidative stress gene data (106) to identify common genes, constructing a protein-protein interaction network (110), and performing a network topology analysis (112) to identify Histone Deacetylase 1 (HDAC1) as a hub gene. The method comprises obtaining a compound library (114), performing molecular docking (116) against HDAC1 to identify a candidate compound based on binding affinity, and performing a molecular dynamics simulation (118) to evaluate binding stability. (Fig. 1)
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