MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202641086432 A) filed by Vels Institute Of Science, Technology And Advanced Studies on July 15, 2026, for Development And Evaluation Of A Nanogel-Based Topical Drug Delivery System For Skin Infections.
Inventors include Dr. Hemamalini. J; Ms. Ramya G. M; Ms. Nandini. G; Ms. Jennifer. N; Ms. Sathya G; Ms. Rexy. R; Ms. Keerthana V. R; Ms. Nancy Hepsibah. E; Ms. Thilagavathi. M; and Dr. G. Saravanan.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: The present invention provides a multi-layer core-shell hybrid nanogel for the topical treatment of bacterial and fungal skin infections. The nanogel comprises a lipid- polymer hybrid core encapsulating a hydrophobic antimicrobial agent, an intermediate pH-responsive chitosan shell crosslinked with sodium tripolyphosphate that swells in the acidic microenvironment of infected skin, and an outer thermoresponsive bioadhesive poloxamer shell carrying a hydrophilic antimicrobial agent such as silver nanoparticles, together with an enzyme-cleavable linker responsive to bacterial lipase and hyaluronidase. The layered architecture co-delivers hydrophilic and hydrophobic antimicrobials with triple-stimuli-responsive release triggered by acidic pH, skin temperature and bacterial enzymes at the infection site. The system provides broad-spectrum synergistic anti-biofilm activity, enhanced dermal penetration, prolonged retention, reduced dosing frequency, minimised systemic exposure and reduced antimicrobial resistance, t
Disclaimer: Curated by HT Syndication.
