MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202511008862 A) filed by Indian Council Of Medical Research on February 03, 2025, for Development Of Cd155/Pvr Knockout Hek-293t Cell Line.
Inventors include Shyam Sundar Nandi; Sonali Ankush Sawant; Ankita Sukhdeo Jagtap; Adriel Braganza; Anushka Jangra; Prasanna Girish Samudra; and Chiranjib Chakraborty.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: The present invention discloses a method for knocking out the CD155/PVR gene of the HEK-293T cell line using CRISPR-CAS9 technology. The present invention also discloses CD155/PVR knockout HEK-293T cell lines which are resistant to poliovirus infection. The present invention further discloses sgRNAs specifically targeting the CD155 gene for knockout. Fig. 1
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