MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202611055721 A) filed by Teerthanker Mahaveer University on May 01, 2026, for Development Of In Situ Chitosan-Based Polyelectrolyte Complexes For Sustained Release Of High-Dose Oral Paracetamol Tablets.
Inventor includes Prof Anurag Verma.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: The present invention relates to a novel method for preparing sustained-release oral pharmaceutical tablets using in situ forming polyelectrolyte complexes (PECs) composed of chitosan and natural anionic polymers such as gum ghatti or xanthan gum. The method involves preparing cooled, neutralized polymeric binder solutions which are used in a wet granulation process to formulate high-dose, water-soluble drugs like paracetamol. Upon exposure to acidic gastric conditions, these polymers interact to form a gel-like PEC barrier that retards drug release. The resulting tablets demonstrate controlled zero-order release over extended periods, improved mechanical properties, and reduced burst effect. This invention provides a simple, scalable, and biocompatible approach for sustained drug delivery without the need for synthetic crosslinkers, offering broad applicability for drugs with short halflives and high solubility.
Disclaimer: Curated by HT Syndication.
