MUMBAI, India, June 24 -- Intellectual Property India has published a patent application (202411091594 A) filed by Council Of Scientific And Industrial Research on November 25, 2024, for Dual Functionalised 3d Printed Scaffold For Bone Tissues Regeneration And Process For Preparation Thereof.
Inventors include Ravi Babu Valapa; Sravanthi Loganathan; and Shubham Pant.
The application for the patent was published on June 12, 2026, under issue no. 24/2026.
Abstract: The present invention relates to a dual functionalised 3D printed scaffold for bone tissues regeneration and a method for the preparation thereof. More specifically, the present invention describes double functionalization of 3D printed poly(lactic acid)/amine grafted mesoporous bioactive glass composite scaffold fn (PLA/fn MBG) containing 30% organic phase and 70% inorganic phase, which mimics natural bone composition. Further, the present invention describes additional surface decoration of polyethylenimine on 3D printed PLA/fn MBG composite scaffold enhancing protein adsorption and cellular attachment, with improved bone cell proliferation. As main outcome of the present invention, the fn (PLA/fn MBG) scaffolds shows higher crystallinity, thermal stability and mechanical properties contributed due to incorporation of 70% amine functioned MBG (fn-MBG). The proliferation rate of MG-63 cells with PLA/fn (MBG) and fn (PLA/fnMBG) scaffolds shows consistent increase. The oestointegration capability of the cell seeded with PLA/fn (MBG) and fn (PLA/fnMBG) scaffolds was observed to be enhanced with up-regulation of COL1 and BMP-2 markers.
Disclaimer: Curated by HT Syndication.
